A validated stability-indicating HPLC method for the simultaneous determination of pheniramine maleate and naphazoline hydrochloride in pharmaceutical formulations

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A validated stability-indicating HPLC method for the simultaneous determination of pheniramine maleate and naphazoline hydrochloride in pharmaceutical formulations

BACKGROUND A simple, rapid, and accurate stability-indicating reverse phase liquid chromatographic method was developed and validated for the simultaneous determination of pheniramine maleate and naphazoline hydrochloride in bulk drugs and pharmaceutical formulations. RESULTS Optimum chromatographic separations among pheniramine maleate, naphazoline hydrochloride and stress-induced degradatio...

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Stability Indicating Hplc Method for Simultaneous Determination of Moxifloxacin Hydrochloride and Ketorolac Tromethamine in Pharmaceutical Formulations

A simple, RP-HPLC method was established for determining moxifloxacin and ketorolac in pharmaceutical formulations. Moxifloxacin, ketorolac and their degradation products were separated using C8 column with methanol and phosphate buffer pH 3.0 (55:45 v/v) as the mobile phase. Detection was performed at 243 nm using a diode array detector. The method was validated using ICH guidelines and was li...

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The proposed study, a new stabilityindicating RP-HPLC method has been developed for estimation of Alogliptin and Pioglitazone in bulk and pharmaceutical dosage form. The present method was a sensitive, precise, and accurate RP-HPLC method for the analysis of Alogliptin and Pioglitazone. To optimize the mobile phase, various combinations of buffer and organic solvents were used on Hypersil BDS C...

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Stability indicating HPLC method for the simultaneous determination of moxifloxacin and prednisolone in pharmaceutical formulations

BACKGROUND A simple, specific, and fast stability indicating reverse phase liquid chromatographic method was established for instantaneous determination of moxifloxacin and prednisolone in bulk drugs and pharmaceutical formulations. RESULTS Optimum chromatographic separations among the moxifloxacin, prednisolone and stress-induced degradation products were achieved within 10 minutes by use of...

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Fluvoxamine maleate is a selective serotonin reuptake inhibitor, which is used for the treatment of different types of depressive disorders. In the present study, a stability indicating HPLC method was developed and validated for the determination of fluvoxamine maleate. The chromatographic separation was carried out using a Nova-Pak CN column and a mixture of K2HPO4 50 mM (pH 7.0) and acetonit...

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ژورنال

عنوان ژورنال: Chemistry Central Journal

سال: 2014

ISSN: 1752-153X

DOI: 10.1186/1752-153x-8-7